Cheesy Chicken Alfredo Bake

First, preheat your oven to a high temperature of 350 degrees Fahrenheit (or 175 degrees Celsius for those using metric measurements).

Next, submerge chicken in a container filled with water and bring to a rolling boil over high heat; then, gradually decrease the heat and continue cooking until the chicken is no longer pink in its center and juices flow freely, taking approximately 15 minutes to achieve this.

Concurrently, bring a substantial amount of salted water to a boil in a large pot. Add penne pasta and cook, stirring occasionally, until the pasta reaches your desired level of tenderness yet still retains a slight firmness to the bite, which typically takes around 11 minutes. Drain the cooked pasta.

Remove the cooked chicken from its container and cut it into small, manageable pieces.

Combine the prepared chicken, cooked pasta, Alfredo sauce, 1/2 cup of mozzarella cheese, milk, onion powder, and garlic powder in a large mixing bowl. Mix everything together thoroughly.

Transfer the mixture into a 1 1/2-quart casserole dish. Layer the remaining mozzarella cheese and Cheddar cheese on top in a single, even layer.

Finally, bake the dish in your preheated oven until the cheese is melted and bubbly, taking approximately 25 minutes to achieve this.